Development and Characterization of an Intraocular Biodegradable Polymer System Containing Cyclosporine-A for the Treatment of Posterior Uveitis
نویسندگان
چکیده
Departamento de Produtos Farmacêuticos, Universidade Federal de Minas Gerais – UFMG, Av. Antônio Carlos, 6627, 31270-010 Belo Horizonte MG, Brazil Departamento de Química, Universidade Federal de Minas Gerais – UFMG Av. Antônio Carlos, 6627, 31270-010 Belo Horizonte MG, Brazil Departamento de Engenharia Metalúrgica e de Materiais, Universidade Federal de Minas Gerias – UFMG, Rua Espírito Santo, 35/316, Centro, 30160-030 Belo Horizonte MG, Brazil
منابع مشابه
Evaluation of cyclosporine A eye penetration after administration of liposomal or conventional forms in animal model
A lot of researches have investigated the effects of topical cyclosporine A on the eye surface layers’ diseases. By now the main limitation in cyclosporine application is the low permeation of the drug into the posterior segments of the eye. The aim of present study was to formulate high permeable dosage form can be beneficial in the topical treatment of the uveitis. To reach higher corneal dru...
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Background: Idiopathic anterior uveitis is an anterior segment inflammation in which a detailed medical history, general and ocular physical examination is not associated with any defined clinical syndrome. Alterations in immune system parameters have been reported in patients with idiopathic posterior uveitis; however no data on the role of immune system in idiopathic anterior uveitis has yet ...
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Uveitis is the third leading cause of blindness in developed countries. Currently, the most widely used treatment of non-infectious uveitis is corticosteroids. Posterior uveitis and macular edema can be treated with intraocular injection of corticosteroids, however, this is problematic in chronic cases because of the need for repeat injections. Another option is systemic immunosuppressive thera...
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